2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113016S
    Elaidic acid-d9 1809227-37-9 98%
    Elaidic acid-d9 is deuterium labeled Elaidic acid. Elaidic acid is the major trans fat found in hydrogenated vegetable oils and can be used as a pharmaceutical solvent.
    Elaidic acid-d9
  • HY-113024R
    Pristanic acid (Standard) 1189-37-3
    D-Mannitol (Standard) is the analytical standard of D-Mannitol. This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells.
    Pristanic acid (Standard)
  • HY-113024S
    Pristanic acid-d3 1383920-14-6 98%
    Pristanic acid-d3 is deuterium labeled Pristanic acid. Pristanic acid is an endogenous metabolite present in Blood that can be used for the research of Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome.
    Pristanic acid-d3
  • HY-113026R
    Delta-Tocopherol (Standard) 119-13-1
    Delta-Tocopherol (Standard) is the analytical standard of Delta-Tocopherol. This product is intended for research and analytical applications. Delta-Tocopherol is an isomer of Vitamin E.
    Delta-Tocopherol (Standard)
  • HY-113033A
    Pentosidine TFA 225784-09-8 98%
    Pentosidine TFA is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine TFA is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease.
    Pentosidine TFA
  • HY-113049A
    Phosphoenolpyruvic acid trisodium 5541-93-5 98%
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) trisodium is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid trisodium is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid trisodium also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid trisodium
  • HY-113058R
    3-Hydroxyoctanoic acid (Standard) 14292-27-4 98%
    3-Hydroxyoctanoic acid (Standard) is the analytical standard of 3-Hydroxyoctanoic acid (HY-113058). 3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet.
    3-Hydroxyoctanoic acid (Standard)
  • HY-113071C
    (S)-Mevalonic acid 32451-23-3 98%
    (S)-Mevalonic acid is the isomer of Mevalonic acid (HY-113071). Mevalonic acid ((S)-DCIT) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure.
    (S)-Mevalonic acid
  • HY-113075S
    1,5-Anhydrosorbitol-13C 2709705-29-1 98%
    1,5-Anhydrosorbitol-13C is the 13C labeled 1,5-Anhydrosorbitol. 1,5-Anhydrosorbitol is a short-term marker for glycemic cont.
    1,5-Anhydrosorbitol-13C
  • HY-113094R
    Paullinic acid (Standard) 17735-94-3
    Diphenmanil (methylsulfate) (Standard) is the analytical standard of Diphenmanil (methylsulfate). This product is intended for research and analytical applications. 0
    Paullinic acid (Standard)
  • HY-113107R
    3-Hydroxydodecanoic acid (Standard) 1883-13-2
    3-Hydroxydodecanoic acid (Standard) is an analytical standard for 3-Hydroxydodecanoic acid. This product is intended for use in research and analytical applications. 3-Hydroxydodecanoic acid is a medium-chain fatty acid. 3-Hydroxydodecanoic acid activates GPR84 and promotes IL-12 production. 3-Hydroxydodecanoic acid has anticancer activity against colon cancer, lung cancer, and melanoma.
    3-Hydroxydodecanoic acid (Standard)
  • HY-113126A
    3-Hydroxyisobutyric acid sodium 1219589-99-7 98%
    3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis.
    3-Hydroxyisobutyric acid sodium
  • HY-113128B
    sn-Glycerol 3-phosphate biscyclohexylammonium salt 29849-82-9 98%
    sn-Glycerol 3-phosphate biscyclohexylammonium salt is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate biscyclohexylammonium salt from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate biscyclohexylammonium salt for lipid metabolism.
    sn-Glycerol 3-phosphate biscyclohexylammonium salt
  • HY-113133R
    Kojibiose (Standard) 2140-29-6
    Kojibiose (Standard) is the analytical standard of Kojibiose. This product is intended for research and analytical applications. Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo[1][2].
    Kojibiose (Standard)
  • HY-113144R
    L-Hexanoylcarnitine (Standard) 22671-29-0
    L-Hexanoylcarnitine (Standard) is the analytical standard of L-Hexanoylcarnitine. This product is intended for research and analytical applications. L-Hexanoylcarnitine is an acylcarnitine and is found to be associated with celiac disease.
    L-Hexanoylcarnitine (Standard)
  • HY-113144S
    L-Hexanoylcarnitine-d9 2847775-84-0 98%
    L-Hexanoylcarnitine-d9 is deuterium labeled L-Hexanoylcarnitine. L-Hexanoylcarnitine is an acylcarnitine and is found to be associated with celiac disease.
    L-Hexanoylcarnitine-d9
  • HY-113162R
    Bovinic acid (Standard) 2540-56-9
    α-Lactose (hydrate) (Standard) is the analytical standard of α-Lactose (hydrate). This product is intended for research and analytical applications. α-Lactose (hydrate) (α-D-Lactose (hydrate)) is the principal carbohydrate in the milk of most mammals. α-Lactose (hydrate) consists of glucose and galactose and exists in the form of two anomers, α and β. α-Lactose (hydrate) has many uses in the food and pharmaceutical industries, such as a free-flowing or agglomerating agent, a diluent for pigments, flavors, or enzymes.
    Bovinic acid (Standard)
  • HY-113166R
    Dodecanoylcarnitine (Standard) 25518-54-1
    Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine. This product is intended for research and analytical applications. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma.
    Dodecanoylcarnitine (Standard)
  • HY-113201R
    Tetradecanoylcarnitine (Standard) 25597-07-3
    Tetradecanoylcarnitine (Standard) is the analytical standard of Tetradecanoylcarnitine. This product is intended for research and analytical applications. Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids.
    Tetradecanoylcarnitine (Standard)
  • HY-113201S
    Tetradecanoylcarnitine-d9 2245713-18-0 98%
    Tetradecanoylcarnitine-d9 is deuterium labeled Tetradecanoylcarnitine. Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids.
    Tetradecanoylcarnitine-d9
Cat. No. Product Name / Synonyms Application Reactivity